Search on: TRANSFORMING GROWTH FACTOR ALPHA 
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Descriptor English:   Transforming Growth Factor alpha 
Descriptor Spanish:   Factor de Crecimiento Transformador alfa 
Descriptor Portuguese:   Fator de Crescimento Transformador alfa 
Synonyms English:   Epidermal Growth Factor-Related Transforming Growth Factor
TGF-alpha  
Tree Number:   D12.644.276.963.700
D12.776.467.960.700
D23.529.960.700
Definition English:   Factor isolated in a variety of tissues including epithelium, and maternal decidua. It is closely related to EPIDERMAL GROWTH FACTOR and binds to the EGF receptor. TGF-alpha acts synergistically with TGF-beta in inducing phenotypic transformation, but its physiological role is unknown. 
History Note English:   91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-ALPHA was see TRANSFORMING GROWTH FACTORS 1989-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   29138 
Unique Identifier:   D016211 

Occurrence in VHL:
 

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